Article
Calbindin D(9k) knockout mice are indistinguishable from wild-type mice in phenotype and serum calcium level.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2006
Kutuzova Galina D, Akhter Shirin, Christakos Sylvia, Vanhooke Janeen, Kimmel-Jehan Christine, Deluca Hector F
Abstract excerpt
Since the discovery of calbindin D(9k), its role in intestinal calcium absorption has remained unsettled. Further, a wide distribution of calbindin D(9k) among tissues has argued for its biological importance. We discovered a frameshift deletion in the calbindin D(9k) gene in an ES cell line, E14.1, that originated from 129/OlaHsd mice. We produced mice with the mutant calbindin D(9k) gene by injecting the E14.1...
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