Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation and characterization of mice with Myh9 deficiency.

Neuromolecular medicine - 1 Jan 2007

Mhatre Anand N, Li Yan, Bhatia Nitin, Wang Kevin H, Atkin Graham, Lalwani Anil K

Abstract excerpt

Mutant alleles of MYH9 encoding a class II non-muscle myosin heavy chain-A (NMMHC-IIA) have been linked to hereditary megathrombocytopenia with or without additional clinical features that include sensorineural deafness, cataracts, and nephritis. To assess its biological role in the affected targets, particularly the inner ear, we have generated and characterized mice with Myh9 deficiency. These mice were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crosses, Genetic
Share to Disease Models, Animal
Share to Ear, Inner

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Hearing Loss

Share to Mice, Transgenic

Share to Myosin Heavy Chains

Share to Organ Specificity

Source

Identifiers

PMID: 17914179
DOI: 10.1007/s12017-007-8008-8

Genes

MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation and characterization of mice with Myh9 deficiency.PMID 17914179Read ↗

Absence of hearing loss in a mouse model for DFNA17 and MYH9-related disease: the use of public gene-targeted ES cell resources.Semantic proximity Read ↗

Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.Semantic proximity Read ↗

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.Semantic proximity Read ↗

Myh9 Plays an Essential Role in the Survival and Maintenance of Hematopoietic Stem/Progenitor CellsSemantic proximity Read ↗

Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO miceSemantic proximity Read ↗

Advances in the understanding of MYH9 disorders.Semantic proximity Read ↗

MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function.Semantic proximity Read ↗

MYH9: Structure, functions and role of non-muscle myosin IIA in human disease.Semantic proximity Read ↗

Late onset and high-frequency dominant hearing loss in a family with MYH9 disorder.Semantic proximity Read ↗

myh9b is a critical non-muscle myosin II encoding gene that interacts with myh9a and myh10 during zebrafish development in both compensatory and redundant pathways.Semantic proximity Read ↗

Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.Semantic proximity Read ↗

Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.