Article
'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice.
Cerebellum (London, England) - 1 Dec 2002
Schwaller Beat, Meyer Michael, Schiffmann Serge
Abstract excerpt
Calretinin (CR), calbindin D-28k (CB) and parvalbumin (PV) belong to the large family of EF-hand calcium-binding proteins, which comprises more than 200 members in man. Structurally these proteins are characterized by the presence of a variable number of evolutionary well-conserved helix-loop-helix motives, which bind Ca2+ ions with high affinity. Functionally, they fall into two groups: by interaction with...
Topics
- Animals
- Calbindin 2
- Calcium
- Cerebellar Ataxia
- Cerebellum
- Homeostasis
- Mice
- Mice, Inbred Strains
- Mice, Knockout
- Motor Activity
- Mutation