Article
In Vitro Primer-Based RNA Elongation and Promoter Fine Mapping of the Respiratory Syncytial Virus.
Journal of virology - 9 Dec 2020
Cao Dongdong, Gao Yunrong, Roesler Claire, Rice Samantha, D'Cunha Paul, Zhuang Lisa, Slack Julia, Antonova Anna, Romanelli Sarah, Liang Bo
Abstract excerpt
Respiratory syncytial virus (RSV) is a nonsegmented negative-sense (NNS) RNA virus and shares a similar RNA synthesis strategy with other members of NNS RNA viruses, such as measles, rabies virus, and Ebola virus. RSV RNA synthesis is catalyzed by a multifunctional RNA-dependent RNA polymerase (RdRP), which is composed of a large (L) protein that catalyzes three distinct enzymatic functions and an essential...
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