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Structural basis of Nipah virus RNA synthesis

6 Mar 2025

Abstract excerpt

Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its RNA-dependent RNA polymerase (RdRp) complex, consisting of the L and P proteins, carries out viral genome replication and transcription and is therefore an attractive drug target. Here, we report cryo-EM structures of the...

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PMID: 40050611
DOI: 10.1038/s41467-025-57219-5

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