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An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene

22 Jun 2005

Abstract excerpt

We have investigated a herpes simplex virus mutant that expresses low levels of thymidine kinase (TK), a phenotype associated with drug resistance and pathogenicity, despite a single-base deletion in the gene. Using a dual-reporter system, a 39-nt sequence including the mutation was shown to direct expression of the downstream reporter gene in reticulocyte lysate. Translation of the downstream reporter was not...

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PMID: 15972803
DOI: 10.1073/pnas.0504132102

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