Analysis of the hotfoot (ho) locus by creation of an insertional mutation in a transgenic mouse.

doi:10.1016/0012-1606(90)90259-l

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Analysis of the hotfoot (ho) locus by creation of an insertional mutation in a transgenic mouse.

Developmental biology - 1 Feb 1990

Gordon J W, Uehlinger J, Dayani N, Talansky B E, Gordon M, Rudomen G S, Neumann P E

Abstract excerpt

Hotfoot (ho) mutation is a recessive trait in mice, characterized by motor disorder and male sterility, that maps to chromosome 6. We have identified a transgenic mouse pedigree with a similar trait. Using genetic and molecular approaches, we have demonstrated that the foreign DNA element is located in or near the ho locus. This new allele, designated hoJwg and presumably created by insertional mutagenesis,...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
DNA
DNA Transposable Elements
Deoxyribonuclease HpaII
Deoxyribonucleases, Type II Site-Specific
Female
Fertilization in Vitro
Gene Library
Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Male

Mice

Mice, Inbred Strains

Mice, Neurologic Mutants

Mice, Transgenic

Microscopy, Electron

Source

Open in PubMed

Identifiers

PMID: 1689261
DOI: 10.1016/0012-1606(90)90259-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1689261-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the hotfoot (ho) locus by creation of an insertional mutation in a transgenic mouse.PMID 1689261Read ↗

Construction of a high-resolution genetic map encompassing the hotfoot locus.Semantic proximity Read ↗

Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine.Semantic proximity Read ↗

Production of knockout mice by gene targeting in multipotent germline stem cells.Semantic proximity Read ↗

Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes.Semantic proximity Read ↗

Wocko, a neurological mutant generated in a transgenic mouse pedigree.Semantic proximity Read ↗

Hotfoot mouse mutations affect the delta 2 glutamate receptor gene and are allelic to lurcher.Semantic proximity Read ↗

A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14.Semantic proximity Read ↗

Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths.Semantic proximity Read ↗

Hand-made cloning approach: potentials and limitationsSemantic proximity Read ↗

Sooty foot, a novel mouse mutation that affects the pigmentation of exposed skin, but not hair, maps to chromosome 2.Semantic proximity Read ↗

Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.Semantic proximity Read ↗

Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.