Article
European multicenter evaluation of high-density DNA probe arrays for detection of hepatitis B virus resistance mutations and identification of genotypes.
Journal of clinical microbiology - 1 Aug 2006
Tran N, Berne R, Chann R, Gauthier M, Martin D, Armand M-A, Ollivet A, Teo C G, Ijaz S, Flichman D, Brunetto M, Bielawski K P, Pichoud C, Zoulim F, Vernet G
Abstract excerpt
Polymorphisms along the hepatitis B virus (HBV) genome have an impact on disease outcome, sensitivity to antiviral treatment, escape from vaccination, and laboratory diagnosis. We have designed a diagnostic tool based on duplex amplification of the whole HBV genome and a high-density DNA chip designed to detect 245 mutations, 20 deletions, and 2 insertions at 151 positions and to determine the genotype of the...
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