Next-Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study.

doi:10.1002/jmv.71130

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Article

Next-Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study.

Journal of medical virology - 1 Sept 2026

Fu Michael X, Perdomo Maria F, Lumley Sheila F, Ringlander Johan, Kean Kai, Reid Kaitlin, Mayne Richard, Montaguth Oscar Enrique Torres, Forrest Leysa, Buddle Sarah, Botha Johannes C, Stenbäck Joakim B, Dickson Zachery, Kent Chris, Chai Haiting, Byott Matthew, Hannolainen Leo, Secret Shannah, Airey George, Hedman Klaus, Andersson Monique I, Ansari M Azim, Nastouli Eleni, Breuer Judith, Matthews Philippa C, Golubchik Tanya, Irving William L, Simmonds Peter, Harvala Heli

Abstract excerpt

This multicentre study investigated the utility of next-generation sequencing (NGS) to detect and generate hepatitis B virus (HBV) genomes in samples of low viral load (from 0.2 to 6207 IU/mL). 23 HBV DNA-positive plasma samples of genotypes A-E and one HBV-negative control sample were assayed blindly via 9 established NGS methods from 6 European laboratories. Methods included untargeted metagenomics,...

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Topics

Humans
DNA, Viral
Europe
Genome, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

Hepatitis B

Hepatitis B virus

High-Throughput Nucleotide Sequencing

Metagenomics

Polymerase Chain Reaction

Sensitivity and Specificity

Viral Load

Source

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Identifiers

PMID: 42683603
DOI: 10.1002/jmv.71130
PMCID: PMC13535886

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