Article
Functional evaluation of the autoimmunity-associated CTLA4 gene: the effect of the (AT) repeat in the 3'untranslated region (UTR).
Journal of autoimmunity - 1 Sept 2006
Anjos Suzana M, Polychronakos Constantin
Abstract excerpt
The third confirmed susceptibility locus in type 1 diabetes (T1D), the CTLA4 gene, harbors several DNA variants in linkage disequilibrium (LD), any one of which, or a combination thereof, could contribute to an individual's susceptibility to disease. Dissecting their contribution to disease requires both genetic and functional studies at each locus, due to the quasi 100% LD in the region. To this effect we have...
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