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Article

Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.

European journal of human genetics : EJHG - 1 Aug 2004

Barreto Marta, Santos Eugénia, Ferreira Ricardo, Fesel Constantin, Fontes Maria Francisca, Pereira Clara, Martins Berta, Andreia Rita, Viana João Faro, Crespo Francisco, Vasconcelos Carlos, Ferreira Carlos, Vicente Astrid Moura

Abstract excerpt

Several lines of evidence implicate the Cytotoxic T Lymphocyte Antigen 4 (CTLA4) gene in susceptibility to autoimmune disease. We have examined the association of systemic lupus erythematosus (SLE) with polymorhisms within the CTLA4 gene that were previously proposed to regulate CTLA-4 function: a single nucleotide polymorphism (SNP) in position +49 of exon 1 and a dinucleotide repeat in the 3' untranslated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15138458
DOI: 10.1038/sj.ejhg.5201214

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.PMID 15138458Read ↗

CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.Semantic proximity Read ↗

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Association between CTLA-4 exon-1 +49A/G polymorphism and systemic lupus erythematosus: an updated analysis.Semantic proximity Read ↗

CTLA-4 gene polymorphism of exon 1(+49 A/G) in Turkish systemic lupus erythematosus patients.Semantic proximity Read ↗

Association of CTLA4 exon-1 polymorphism with the tumor necrosis factor-α in the risk of systemic lupus erythematosus among South Indians.Semantic proximity Read ↗

A CTLA-4 polymorphism associated with susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

Cytotoxic T Lymphocyte Antigen 4 Gene +49 A/G (rs231775) Polymorphism and Susceptibility to Systemic Lupus Erythematosus.Semantic proximity Read ↗

CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States.Semantic proximity Read ↗

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CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.Semantic proximity Read ↗

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