Article
The NOS3 (27-bp repeat, intron 4) polymorphism is associated with susceptibility to osteomyelitis.
Nitric oxide : biology and chemistry - 1 Feb 2007
Asensi Victor, Montes A Hugo, Valle Eulalia, Ocaña Marcos G, Astudillo Aurora, Alvarez Victoria, López-Anglada Esteban, Solís Angeles, Coto Eliecer, Meana Alvaro, Gonzalez Pelayo, Carton Jose A, Paz Jose, Fierer Joshua, Celada Antonio
Abstract excerpt
Cytokines generate nitric oxide (NO) in osteoblasts and neutrophils through the induction of NO synthase isoforms, endothelial (NOS3) and inducible (NOS2), thereby producing bone loss. In osteomyelitis (OM), a chronic infection of the bone, homozygosity for the NOS3 (27-bp repeat, intron 4 polymorphism) 4 allele was significantly more frequent among the 80 patients than in 300 healthy controls (p=0.044). No...
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