Single base substitution in codon 74 of the MD rat myelin proteolipid protein gene.

doi:10.1111/j.1749-6632.1990.tb42389.x

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Article

Single base substitution in codon 74 of the MD rat myelin proteolipid protein gene.

Annals of the New York Academy of Sciences - 1 Jan 1990

Simons R, Riordan J R

Abstract excerpt

The myelin-deficient (md) rat is one of several X-linked animal mutants that have severe dysmyelination in the central nervous system. It appears in all to be the result of mutations in the myelin proteolipid protein gene which is located on the long arm of the X-chromosome. To identify the md rat mutation, we isolated and sequenced cDNAs corresponding to PLP and DM-20 mRNAs from the brain of hemizygous affected...

Topics

Aging
Animals
Base Sequence
Brain
Codon
Exons
Introns
Male
Molecular Sequence Data
Mutation
Myelin Proteins
Myelin Proteolipid Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymerase Chain Reaction

RNA

RNA, Messenger

Rats

Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 1702593
DOI: 10.1111/j.1749-6632.1990.tb42389.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1702593-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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