Article
Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype.
Molecular cancer therapeutics - 1 Dec 2011
Emmons Michael F, Gebhard Anthony W, Nair Rajesh R, Baz Rachid, McLaughlin Mark L, Cress Anne E, Hazlehurst Lori A
Abstract excerpt
We recently reported that the β1 integrin antagonist, referred to as HYD1, induces necrotic cell death in myeloma cell lines as a single agent using in vitro and in vivo models. In this article, we sought to delineate the determinants of sensitivity and resistance toward HYD1-induced cell death. To this end, we developed an HYD1 isogenic resistant myeloma cell line by chronically exposing H929 myeloma cells to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.