Article
Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype.
Molecular cancer therapeutics - 1 Dec 2011
Emmons Michael F, Gebhard Anthony W, Nair Rajesh R, Baz Rachid, McLaughlin Mark L, Cress Anne E, Hazlehurst Lori A
Abstract excerpt
We recently reported that the β1 integrin antagonist, referred to as HYD1, induces necrotic cell death in myeloma cell lines as a single agent using in vitro and in vivo models. In this article, we sought to delineate the determinants of sensitivity and resistance toward HYD1-induced cell death....
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