A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.

doi:10.1073/pnas.87.1.323

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Article

A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990

Auld V J, Goldin A L, Krafte D S, Catterall W A, Lester H A, Davidson N, Dunn R J

Abstract excerpt

Sodium channels encoded by the rat IIA cDNA clone [Auld, V. J., Goldin, A. L., Krafte, D. S., Marshall, J., Dunn, J., Catterall, W. A., Lester, H. A., Davidson, N. & Dunn, R. J. (1988) Neuron 1, 449-461] differ at seven amino acid residues from those encoded by the rat II cDNA [Noda, M., Ikeda, T...

Topics

Amino Acid Sequence
Animals
Brain
Cloning, Molecular
DNA
Female
Leucine
Macromolecular Substances
Membrane Potentials
Membrane Proteins
Microinjections
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oocytes

Phenylalanine

Poly A

Protein Biosynthesis

RNA

Source

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Identifiers

PMID: 1688658
DOI: 10.1073/pnas.87.1.323
PMCID: PMC53255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1688658-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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