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Article

Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors.

American journal of physiology. Cell physiology - 1 Jan 2007

Allen David L, Unterman Terry G

Abstract excerpt

Myostatin, a member of the transforming growth factor (TGF)-beta family, plays an important role in regulating skeletal muscle growth and differentiation. Here we examined the role of FoxO1 and SMAD transcription factors in regulating myostatin gene expression and myoblast differentiation in C(2)C(12) myotubes in vitro. Both myostatin and FoxO1 mRNA expression were greater in fast- vs. slow-twitch skeletal...

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Share to Forkhead Box Protein O1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Fibers, Fast-Twitch

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Source

Identifiers

PMID: 16885393
DOI: 10.1152/ajpcell.00542.2005

Genes

SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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