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Article

The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.

Molecular cell - 4 Aug 2006

Small Eliza C, Leggett Stephanie R, Winans Adrienne A, Staley Jonathan P

Abstract excerpt

Binding of a pre-mRNA substrate triggers spliceosome activation, whereas the release of the mRNA product triggers spliceosome disassembly. The mechanisms that underlie the regulation of these rearrangements remain unclear. We find evidence that the GTPase Snu114p mediates the regulation of spliceosome activation and disassembly. Specifically, both unwinding of U4/U6, required for spliceosome activation, and...

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Share to Guanosine Diphosphate
Share to Ribonucleoprotein, U5 Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16885028
DOI: 10.1016/j.molcel.2006.05.043
PMCID: PMC3777414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.PMID 16885028Read ↗

Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.Semantic proximity Read ↗

Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation.Semantic proximity Read ↗

Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing.Semantic proximity Read ↗

A U1-U2 snRNP interaction network during intron definition.Semantic proximity Read ↗

The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome.Semantic proximity Read ↗

Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing.Semantic proximity Read ↗

Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome.Semantic proximity Read ↗

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.Semantic proximity Read ↗

FRG1 Regulates Nonsense-Mediated mRNA Decay by Modulating UPF1 LevelsSemantic proximity Read ↗

Brr2p-mediated unwinding of U4/U6 is promoted by a mutually exclusive intra-molecular stem loop in U4 and involves destabilization of the 5’ stem-loop of U4Semantic proximity Read ↗

RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2.Semantic proximity Read ↗

The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.Semantic proximity Read ↗

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