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Article

Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome.

Genetics - 1 Oct 2009

Frazer Lily Novak, Lovell Simon C, O'Keefe Raymond T

Abstract excerpt

Conformational changes of snRNAs in the spliceosome required for pre-mRNA splicing are regulated by eight ATPases and one GTPase Snu114p. The Snu114p guanine state regulates U4/U6 unwinding during spliceosome activation and U2/U6 unwinding during spliceosome disassembly through the ATPase Brr2p....

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Share to Base Pairing
Share to Catalytic Domain
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Ribonucleoprotein, U5 Small Nuclear

Share to RNA, Small Nuclear

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Share to Suppression, Genetic

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Identifiers

PMID: 19620389
DOI: 10.1534/genetics.109.107243
PMCID: PMC2766312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19620389-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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