Article
A de novo mutation in KIT causes white spotting in a subpopulation of German Shepherd dogs.
Animal genetics - 1 Jun 2013
Wong A K, Ruhe A L, Robertson K R, Loew E R, Williams D C, Neff M W
Abstract excerpt
Although variation in the KIT gene is a common cause of white spotting among domesticated animals, KIT has not been implicated in the diverse white spotting observed in the dog. Here, we show that a loss-of-function mutation in KIT recapitulates the coat color phenotypes observed in other species. A spontaneous white spotting observed in a pedigree of German Shepherd dogs was mapped by linkage analysis to a...
Topics
- Animals
- Chromosome Mapping
- Computational Biology
- Dogs
- Female
- Frameshift Mutation
- Genetic Linkage
- Genetic Pleiotropy
- Genetic Variation
- Genotype
- Hair Color
- Homozygote
- Pedigree
- Proto-Oncogene Proteins c-kit
- Sequence Analysis, DNA