Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.

Journal of cellular physiology - 1 Nov 2006

Huang Yu-Chun, Hung Wen-Chun

Abstract excerpt

Upregulation of p27Kip1 protein in 1,25-dihydroxyvitamin D3-treated cancer cells is mediated via enhancement of gene transcription and reduction of protein degradation. 1,25-dihydroxyvitamin D3 inhibits the expression of p45Skp2, the F-box protein which is implicated in p27Kip1 degradation, to reduce turnover of p27Kip1 protein. In this study, we elucidate the underlying mechanism by which 1,25-dihydroxyvitamin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Calcitriol
Share to Histone Deacetylase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Prostatic Neoplasms

Share to Receptors, Calcitriol

Share to S-Phase Kinase-Associated Proteins

Share to Sp1 Transcription Factor

Source

Identifiers

PMID: 16883603
DOI: 10.1002/jcp.20741

Genes

HDAC1
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.PMID 16883603Read ↗

Analysis of vitamin D‐regulated gene expression in LNCaP human prostate cancer cells using cDNA microarraysSemantic proximity Read ↗

Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene ExpressionSemantic proximity Read ↗

Regulation of the human vitamin D3 receptor promoter in breast cancer cells is mediated through Sp1 sites.Semantic proximity Read ↗

Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells.Semantic proximity Read ↗

Regulation of multiple insulin-like growth factor binding protein genes by 1 ,25-dihydroxyvitamin D3Semantic proximity Read ↗

Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter.Semantic proximity Read ↗

Sp1 and NF-Y Synergistically Mediate the Effect of Vitamin D3 in the p27Kip1 Gene Promoter That Lacks Vitamin D Response ElementsSemantic proximity Read ↗

Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cellsSemantic proximity Read ↗

Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells.Semantic proximity Read ↗

A role for the phosphatidylinositol 3-kinase--protein kinase C zeta--Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24-hydroxylase gene in human kidney cells.Semantic proximity Read ↗

Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter.Semantic proximity Read ↗

Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.