Article
Regulation of the human vitamin D3 receptor promoter in breast cancer cells is mediated through Sp1 sites.
Molecular and cellular endocrinology - 31 Jan 2005
Wietzke Jennifer A, Ward Erin C, Schneider John, Welsh JoEllen
Abstract excerpt
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of Vitamin D, mediates gene transcription through the Vitamin D receptor (VDR), a nuclear receptor expressed in multiple normal and transformed cell types. In mammary epithelial cells, including those derived from breast cancers, 1,25(OH)(2)D(3) induces growth arrest and/or apoptosis through VDR dependent mechanisms, and VDR agonists represent...
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