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Article

Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells

6 Jan 2005

Abstract excerpt

The transactivation function of the human androgen receptor (AR) can be regulated by several coregulators that may be either positive or negative. Ubiquitous transcription factor Sp1 not only regulates the basal expression of the AR but also acts as its coregulator. Our previous study has shown that quercetin, one of the main polyphenols, can effectively inhibit the expression and function of the AR. The present...

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Share to Estrogen and related hormone effects
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15661808
DOI: 10.1093/carcin/bgi021

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Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cellsPMID 15661808Read ↗

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Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.Semantic proximity Read ↗

1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.Semantic proximity Read ↗

Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene ExpressionSemantic proximity Read ↗

Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells.Semantic proximity Read ↗

Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells.Semantic proximity Read ↗

Ubiquitous transcription factors NF1 and Sp1 are involved in the androgen activation of the mouse vas deferens protein promoter.Semantic proximity Read ↗

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