Article
Regulation of multiple insulin-like growth factor binding protein genes by 1 ,25-dihydroxyvitamin D3
25 Sept 2005
Abstract excerpt
Recently, insulin-like growth factor binding proteins (IGFBPs) have been found to be primary mediators of the anti-proliferative actions of the nuclear hormone 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], but dependent on cellular context IGFBPs can also have a mitogenic effect. In this study, we performed expression profiling of all six human IGFBP genes in prostate and bone cancer cells and demonstrated...
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