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Article

Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter.

Molecular endocrinology (Baltimore, Md.) - 1 May 2004

Peng Lihong, Malloy Peter J, Feldman David

Abstract excerpt

1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] plays a critical role in maintaining calcium and phosphate homeostasis and bone formation but also exhibits antiproliferative activity on many cancer cells, including prostate cancer. We have shown that the antiproliferative actions of 1,25-(OH)2D3 in the LNCaP human prostate cancer cell line are mediated in part by induction of IGF binding protein-3 (IGFBP-3). The purpose...

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Identifiers

PMID: 14963110
DOI: 10.1210/me.2003-0344

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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