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Article

Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 2004

Ebert Regina, Jovanovic Marlena, Ulmer Matthias, Schneider Doris, Meissner-Weigl Jutta, Adamski Jerzy, Jakob Franz

Abstract excerpt

1,25-(OH)(2) vitamin D(3) is important for calcium homeostasis and cell differentiation. The key enzyme for the activation of liver-derived 25(OH) vitamin D(3) is 25-hydroxyvitamin D(3) 1alpha-hydroxylase. It is expressed mainly in the kidney but also in peripheral tissues. A 1413-bp fragment of the 1alpha-hydroxylase promoter was cloned into luciferase vectors pGL2basic and pGL3basic. Sequence analyses revealed...

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Identifiers

PMID: 15243130
DOI: 10.1210/me.2002-0441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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