Article
A role for the phosphatidylinositol 3-kinase--protein kinase C zeta--Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24-hydroxylase gene in human kidney cells.
Cellular signalling - 1 Mar 2010
Dwivedi Prem P, Gao Xiu-Hui, Tan Joseph Cheng-Ta, Evdokiou Andreas, Ferrante Antonio, Morris Howard A, May Brian K, Hii Charles S T
Abstract excerpt
The molecular mechanisms that underlie non-genomic induction of the 25-hydroxyvitamin D3 24-hydroxylase (CYP24) gene promoter by the steroid hormone, 1,25-Dihydroxyvitamin D3 (1,25D), are poorly understood. Although we have previously identified a functional inverted GC-box in the early promoter at -113/-105 bp, it is not known whether this site is important for 1,25D induction of the promoter. Using transfected...
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