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Article

Lead exposure is associated with decreased serum paraoxonase 1 (PON1) activity and genotypes.

Environmental health perspectives - 1 Aug 2006

Li Wan-Fen, Pan Mei-Hung, Chung Meng-Chu, Ho Chi-Kung, Chuang Hung-Yi

Abstract excerpt

Lead exposure causes cardiac and vascular damage in experimental animals. However, there is considerable debate regarding the causal relationship between lead exposure and cardiovascular dysfunction in humans. Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, is capable of hydrolyzing oxidized lipids and thus protects against atherosclerosis. Previous studies have shown that lead and...

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Identifiers

PMID: 16882531
DOI: 10.1289/ehp.9163
PMCID: PMC1552024

Genes

PON1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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