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Article

Association of lead, cadmium and mercury with paraoxonase 1 activity and malondialdehyde in a general population in Southern Brazil.

Environmental research - 1 Jul 2017

Almeida Lopes Ana Carolina Bertinde, Urbano Mariana Ragassi, Souza-Nogueira André de, Oliveira-Paula Gustavo H, Michelin Ana Paula, Carvalho Maria de Fátima H, Camargo Alissana Ester Iakmiu, Peixe Tiago Severo, Cabrera Marcos Aparecido Sarria, Paoliello Monica Maria Bastos

Abstract excerpt

Metal exposure is associated with increased oxidative stress (OS), which is considered an underlying mechanism of metal-induced toxicity. Malondialdehyde (MDA) is a final product of lipid peroxidation, and it has been extensively used to evaluate metal-induced OS. Pro-oxidant effects produced by metals can be mitigated by paraoxonase 1 (PON1), an antioxidant enzyme known to prevent cardiovascular disease and...

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Source

Identifiers

PMID: 28477577
DOI: 10.1016/j.envres.2017.04.036

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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