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Article

The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence

16 May 2009

Abstract excerpt

Oncogene-induced senescence acts as a barrier against tumour formation and has been implicated as the mechanism preventing the transformation of benign melanocytic lesions that frequently harbour oncogenic B-RAF or N-RAS mutations. In the present study we systematically assessed the relative importance of the tumour suppressor proteins p53, p21(Waf1), pRb and p16(INK4a) in mediating oncogene-induced senescence in...

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PMID: 20157537
DOI: 10.18632/aging.100051

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