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Article

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

The Journal of clinical investigation - 1 Jan 2002

Mauvais-Jarvis Franck, Ueki Kohjiro, Fruman David A, Hirshman Michael F, Sakamoto Kei, Goodyear Laurie J, Iannacone Matteo, Accili Domenico, Cantley Lewis C, Kahn C Ronald

Abstract excerpt

A critical component of insulin action is the enzyme phosphoinositide (PI) 3-kinase. The major regulatory subunits of PI 3-kinase, p85alpha and its splice variants, are encoded by the Pik3r1 gene. Heterozygous disruption of Pik3r1 improves insulin signaling and glucose homeostasis in normal mice and mice made insulin-resistant by heterozygous deletion of the Insulin receptor and/or insulin receptor substrate-1...

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Share to Diabetes Mellitus, Experimental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Mutant Strains

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Source

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Identifiers

PMID: 11781359
DOI: 10.1172/JCI13305
PMCID: PMC150818

Genes

IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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