Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2010

Chagpar Ryaz B, Links Philip H, Pastor M Chris, Furber Levi A, Hawrysh Andrea D, Chamberlain M Dean, Anderson Deborah H

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in many human diseases including cancer, diabetes, obesity, and autoimmunity. PI3K consists of a p110 catalytic protein and a p85alpha regulatory protein, required for the stabilization and localization of p110-PI3K activity. The p110-PI3K enzyme generates the key signaling lipid phosphatidylinositol 3,4,5-trisphosphate, which is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Peptide Fragments

Share to Phosphatidylinositol 3-Kinases

Share to Protein Interaction Domains and Motifs

Share to Protein Subunits

Share to PTEN Phosphohydrolase

Source

Open in PubMed Open full text

Identifiers

PMID: 20212113
DOI: 10.1073/pnas.0908899107
PMCID: PMC2851819

Genes

PTEN
PI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.PMID 20212113Read ↗

The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling.Semantic proximity Read ↗

The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor SignalingSemantic proximity Read ↗

Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.Semantic proximity Read ↗

The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.Semantic proximity Read ↗

The PTEN–PI3K Axis in CancerSemantic proximity Read ↗

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Semantic proximity Read ↗

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85βSemantic proximity Read ↗

The PTEN-PI3K Axis in CancerSemantic proximity Read ↗

PTEN and the PI3-kinase pathway in cancer.Semantic proximity Read ↗

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.Semantic proximity Read ↗

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.Semantic proximity Read ↗

The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.