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Mismatch repair and treatment resistance in ovarian cancer

31 Jul 2006

Abstract excerpt

BACKGROUND: The treatment of ovarian cancer is hindered by intrinsic or acquired resistance to platinum-based chemotherapy. The aim of this study is to determine the frequency of mismatch repair (MMR) inactivation in ovarian cancer and its association with resistance to platinum-based chemotherapy. METHODS: We determined, microsatellite instability (MSI) as a marker for MMR inactivation (analysis of BAT25 and...

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PMID: 16879751
DOI: 10.1186/1471-2407-6-201

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