Article
Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2009
Honecker Friedemann, Wermann Hendrik, Mayer Frank, Gillis Ad J M, Stoop Hans, van Gurp Ruud J L M, Oechsle Karin, Steyerberg Ewout, Hartmann Jörg Th, Dinjens Winand N M, Oosterhuis J Wolter, Bokemeyer Carsten, Looijenga Leendert H J
Abstract excerpt
PURPOSE: Mismatch repair (MMR) deficiency and microsatellite instability (MSI) are associated with cisplatin resistance in human germ cell tumors (GCTs). BRAF mutation (V600E) is found in MSI colorectal cancers. The role of RAS/RAF pathway mutations in GCT treatment response is unknown. PATIENTS AND METHODS: Two patient cohorts were investigated: 100 control GCTs (50 seminomas and 50 nonseminomas) and 35...
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