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Article

A change in microsatellite instability caused by cisplatin-based chemotherapy of ovarian cancer

1 Oct 2001

Abstract excerpt

To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after 5 or 6 courses of CDDP-based chemotherapy in the 24 cases of ovarian cancer. Of the 24 primary...

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PMID: 11592780
DOI: 10.1054/bjoc.2001.2037

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