Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma.

Cancer - 15 Nov 2003

Geisler John P, Goodheart Michael J, Sood Anil K, Holmes Richard J, Hatterman-Zogg Melanie A, Buller Richard E

Abstract excerpt

BACKGROUND: hMLH1, the human MutL homologue, has been linked to microsatellite instability (MSI) in gastrointestinal tumors. However, to the authors' knowledge, the role of hMLH1, the other mismatch repair genes (MMR), and MSI in ovarian carcinoma has not been well defined. The purpose of the current study was to determine the relation between MSI of ovarian carcinoma and MMR gene expression, hMLH1 and hMSH2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Base Pair Mismatch

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma

Share to DNA, Complementary

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Proteins

Share to Ovarian Neoplasms

Source

Identifiers

PMID: 14601090
DOI: 10.1002/cncr.11770

Genes

PMS1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma.PMID 14601090Read ↗

Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.Semantic proximity Read ↗

Frequent LOH at hMLH1, a highly variable SNP in hMSH3, and negligible coding instability in ovarian cancer.Semantic proximity Read ↗

hMLH1 and hMSH2 expression in human hepatocellular carcinomaSemantic proximity Read ↗

High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.Semantic proximity Read ↗

Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines.Semantic proximity Read ↗

A review of the clinical relevance of mismatch‐repair deficiency in ovarian cancerSemantic proximity Read ↗

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial CancersSemantic proximity Read ↗

MSH3 protein expression and nodal status in MLH1-deficient colorectal cancers.Semantic proximity Read ↗

Mismatch repair gene mutations in renal cell carcinoma.Semantic proximity Read ↗

MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile.Semantic proximity Read ↗

Microsatellite instability and mutation analysis of candidate genes in unselected sardinian patients with endometrial carcinoma.Semantic proximity Read ↗

The profile of hMLH1 methylation and microsatellite instability in colorectal and non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.