Article
Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) Study.
Human heredity - 1 Jan 2006
Njajou O T, Alizadeh B Z, Aulchenko Y, Zillikens M C, Pols H A P, Oostra B A, Swinkels D W, van Duijn C M
Abstract excerpt
BACKGROUND: Iron has been implicated in the pathogenesis of various disorders. Mutations in the HFE gene are associated with an increase in serum iron parameters. The aim of this study was to estimate the heritability in serum iron parameters explained by HFE. METHODS: Ninety families (980 subjects) were included in the present analysis. Heritability estimation was conducted using the variance component method....
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