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Article

Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.

Journal of medical genetics - 1 Sept 2013

Galesloot Tessel E, Geurts-Moespot Anneke J, den Heijer Martin, Sweep Fred C G J, Fleming Robert E, Kiemeney Lambertus A L M, Vermeulen Sita H, Swinkels Dorine W

Abstract excerpt

BACKGROUND: Genome-wide association studies have convincingly shown that single nucleotide polymorphisms (SNPs) in HFE and TMPRSS6 are associated with iron parameters. It was commonly thought that these associations could be explained by the intermediate effect on hepcidin concentration. A recent study in an isolated Italian population, however, concluded that these associations were not exclusively dependent on...

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Source

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Identifiers

PMID: 23794717
DOI: 10.1136/jmedgenet-2013-101673
PMCID: PMC7784039

Genes

HFE
TMPRSS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.PMID 23794717Read ↗

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