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Article

Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors.

Journal of biochemistry - 1 Jul 2006

Tsukuba Takayuki, Yamamoto Shinya, Yanagawa Michiyo, Okamoto Kuniaki, Okamoto Yoshiko, Nakayama Keiichi I, Kadowaki Tomoko, Yamamoto Kenji

Abstract excerpt

Cathepsin E, an intracellular aspartic proteinase, is predominantly localized in the endosomal compartments of immune system cells. In the present study, we investigated the role of cathepsin E in immune defense systems against bacterial infection. Cathepsin E-deficient (CatE(-/-)) mice showed dramatically increased susceptibility to infection with both the Gram-positive bacterium Staphyrococcus aureus, and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16877769
DOI: 10.1093/jb/mvj132

Genes

TLR2
TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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