Article
Murine cytomegalovirus independently inhibits priming of helper and cytotoxic T lymphocytes.
Virology - 1 Nov 1991
Slater J S, Futch W S, Cavanaugh V J, Campbell A E
Abstract excerpt
Murine cytomegalovirus (MCMV) inhibits antigen-specific cytotoxic T lymphocyte (CTL) priming in vivo (Campbell et al., 1989). To address the mechanism of this immune suppression, two possibilities were considered: (1) MCMV directly interferes with in vivo priming of CTL precursors (CTLp), or (2) MCMV suppresses T helper cell functions necessary for CTL priming. We therefore quantitated T helper cell function in...
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