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Article

Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity.

Immunologic research - 1 Aug 2011

Di Caro Valentina, D'Anneo Antonella, Phillips Brett, Engman Carl, Harnaha Jo, Trucco Massimo, Giannoukakis Nick

Abstract excerpt

Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha- CD11c+ CD11b+ DC. These DC exhibited low surface class I and class II MHC, CD40, and CD86 and...

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Source

Identifiers

PMID: 21476100
DOI: 10.1007/s12026-011-8206-1

Genes

TLR9
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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