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Article

ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes

4 Jun 2013

Abstract excerpt

Endochondral ossification is a highly regulated process that relies on properly orchestrated cell-cell interactions in the developing growth plate. This study is focused on understanding the role of a crucial regulator of cell-cell interactions, the membrane-anchored metalloproteinase ADAM17, in endochondral ossification. ADAM17 releases growth factors, cytokines, and other membrane proteins from cells and is...

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PMID: 23732913
DOI: 10.1128/mcb.00291-13

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