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Article

Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.

Arthritis and rheumatism - 1 Aug 2006

Kaufman Kenneth M, Kelly Jennifer A, Herring Billy J, Adler Adam J, Glenn Stuart B, Namjou Bahram, Frank Summer G, Dawson Sarah L, Bruner Gail R, James Judith A, Harley John B

Abstract excerpt

OBJECTIVE: The R620W (1858C-->T) polymorphism in PTPN22 has been implicated in type 1 diabetes mellitus, rheumatoid arthritis, Graves' disease, Hashimoto thyroiditis, autoimmune thyroid disease, and systemic lupus erythematosus (SLE). The aim of this study was to evaluate this polymorphism in patients with familial SLE and in those with sporadic SLE. METHODS: A total of 4,981 DNA samples were genotyped (from...

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Identifiers

PMID: 16868974
DOI: 10.1002/art.21963

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.PMID 16868974Read ↗

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.Semantic proximity Read ↗

Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.Semantic proximity Read ↗

PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.Semantic proximity Read ↗

The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update.Semantic proximity Read ↗

PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility.Semantic proximity Read ↗

R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity.Semantic proximity Read ↗

Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete.Semantic proximity Read ↗

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PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results.Semantic proximity Read ↗

Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.Semantic proximity Read ↗

Contribution of the R620W polymorphism of protein tyrosine phosphatase non-receptor 22 to systemic lupus erythematosus in Poland.Semantic proximity Read ↗

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