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Article

Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.

The Journal of international medical research - 1 Jan 2000

Takeda R, Kamano T, Sakamoto K, Sugano M, Hosoda S, Watanabe T, Maeda T, Kojima Y

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism may influence the chemosensitivity of colorectal cancers to fluorouracil (5-FU) by increasing intracellular 5,10-methylenetetrahydrofolate. The effect of this polymorphism on the expression of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT) and thymidine phosphorylase (TP) in colorectal...

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Source

Identifiers

PMID: 16866026
DOI: 10.1177/147323000603400311

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.PMID 16866026Read ↗

The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells.Semantic proximity Read ↗

A study of the MTHFR gene polymorphism C677T in colorectal cancer.Semantic proximity Read ↗

Correlation between thymidylate synthase gene variants, RNA and protein levels in primary colorectal adenocarcinomas.Semantic proximity Read ↗

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivitySemantic proximity Read ↗

Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.Semantic proximity Read ↗

Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers.Semantic proximity Read ↗

Relationship between thymidylate synthase (TS) genotype and TS expression: a tissue microarray analysis of colorectal cancers.Semantic proximity Read ↗

<i>Thymidylate Synthase</i> and <i>Methylenetetrahydrofolate Reductase</i> Gene Polymorphism in Normal Tissue As Predictors of Fluorouracil SensitivitySemantic proximity Read ↗

Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.Semantic proximity Read ↗

Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.Semantic proximity Read ↗

TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.Semantic proximity Read ↗

TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.Semantic proximity Read ↗

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