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<i>Thymidylate Synthase</i> and <i>Methylenetetrahydrofolate Reductase</i> Gene Polymorphism in Normal Tissue As Predictors of Fluorouracil Sensitivity

26 Feb 2005

Abstract excerpt

PURPOSE: To analyze thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with respect to fluorouracil (FU) sensitivity. PATIENTS AND METHODS: The study included a retrospective analysis of 88 patients with metastatic colorectal cancer and a prospective trial with 51 patients also with measurable metastases. All patients were treated with FU and leucovorin. The analysis of...

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PMID: 15735113
DOI: 10.1200/jco.2005.06.219

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