Tumor necrosis factor alpha in murine systemic lupus erythematosus disease models: implications for genetic predisposition and immune regulation.

doi:10.1016/1043-4666(91)90481-r

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Article

Tumor necrosis factor alpha in murine systemic lupus erythematosus disease models: implications for genetic predisposition and immune regulation.

Cytokine - 1 Nov 1991

Jacob C O, Hwang F, Lewis G D, Stall A M

Abstract excerpt

Recombinant tumor necrosis factor alpha (TNF-alpha) administration significantly delayed the development of lupuslike nephritis in the New Zealand black x New Zealand white (NZB x NZW)F1 and to a lesser extent in the MRL-lpr/lpr model systems. TNF-alpha treatment was effective when treatment was...

Topics

Animals
Antibodies, Antinuclear
Base Sequence
Disease Models, Animal
Genetic Predisposition to Disease
Histocompatibility Antigens Class II
Lupus Erythematosus, Systemic
Lupus Nephritis
Macrophages
Mice
Mice, Inbred NZB
Mice, Mutant Strains
Molecular Sequence Data
Polymorphism, Restriction Fragment Length
Recombinant Proteins
Tumor Necrosis Factor-alpha

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PMID: 1686413
DOI: 10.1016/1043-4666(91)90481-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1686413-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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