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Article

Toward understanding the inactivation mechanism of monooxygenase P450 BM-3 by organic cosolvents: a molecular dynamics simulation study.

Biopolymers - 5 Dec 2006

Roccatano Danilo, Wong Tuck Seng, Schwaneberg Ulrich, Zacharias Martin

Abstract excerpt

Cytochrome P450 BM-3 from Bacillus megaterium is an extensively studied enzyme for industrial applications. A major focus of current protein engineering research is directed to improving the catalytic performance of P450 BM-3 toward nonnatural substrates of industrial importance in the presence of organic solvents or cosolvents. For the latter reason, it is important to study the effect of organic cosolvent...

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PMID: 16862534
DOI: 10.1002/bip.20577

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