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Article

Effect of Cytochrome P450 3A4 Genetic Polymorphisms on Heme Recognition by Using Molecular Dynamics Simulations.

Biological & pharmaceutical bulletin - 1 Jan 2026

Mizuno Ayato, Nakayoshi Tomoki, Mizutani Emi, Hiratsuka Masahiro, Kato Koichi, Oda Akifumi

Abstract excerpt

CYP3A4 is a drug-metabolizing enzyme involved in the metabolism of numerous drugs, and genetic polymorphisms of CYP3A4 can influence individual differences in drug toxicity and efficacy. For some variants, it has been reported that not only were the enzymatic activities reduced, but also the 450 nm absorption spectra in the presence of CO were lost. In this study, molecular dynamics simulations of CYP3A4.1,...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41905950
DOI: 10.1248/bpb.b26-00029

Genes

CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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