Article
APC and beta-catenin in alveolar soft part sarcoma (ASPS)--immunohistochemical and molecular genetic analysis.
Pathology, research and practice - 1 Jan 2000
Kuhnen C, Herter P, Monse H, Kahmann S, Muehlberger T, Vogt P M, Steinau H U, Müller K M, Müller O
Abstract excerpt
Apart from its role in cell-adhesion, beta-catenin is regarded as an oncoprotein, the cytoplasmic level of which is regulated by APC as a tumor suppressor protein. Changes of chromosome 5q, the region that includes the APC-gene, are known to be important in the pathogenesis of fibromatosis; however, little is known about the significance of APC and beta-catenin in other mesenchymal tumors. Therefore, we used...
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