Article
Low frequency of beta-catenin gene mutations in pilomatricoma.
Acta dermato-venereologica - 1 Jan 2002
Ha Seog-Jun, Kim Jung-Soo, Seo Eun-Joo, Lee Kyung-Ho, Lee Hyun-Jeong, Kim Jin-Wou
Abstract excerpt
We investigated beta-catenin and adenomatous polyposis coli (APC) gene abnormalities in human pilomatricoma, in which a high incidence of beta-catenin gene mutations has been reported. Nucleated tumour cells were microdissected from 20 paraffin-embedded pilomatricomas. Exon 3 of the beta-catenin gene was amplified using polymerase chain reaction and sequencing analysis was performed. Immunostaining for...
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