Article
APC-dependent suppression of colon carcinogenesis by PPARgamma.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002
Girnun Geoffrey D, Smith Wendy M, Drori Stavit, Sarraf Pasha, Mueller Elisabetta, Eng Charis, Nambiar Prashant, Rosenberg Daniel W, Bronson Roderick T, Edelmann Winfried, Kucherlapati Raju, Gonzalez Frank J, Spiegelman Bruce M
Abstract excerpt
Activation of PPARgamma by synthetic ligands, such as thiazolidinediones, stimulates adipogenesis and improves insulin sensitivity. Although thiazolidinediones represent a major therapy for type 2 diabetes, conflicting studies showing that these agents can increase or decrease colonic tumors in mice have raised concerns about the role of PPARgamma in colon cancer. To analyze critically the role of this receptor,...
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